NFL Week 10 odds, picks
Post sports gambling editor/producer and digital sports editor Matt Ehalt is back for his second season in the NFL Bettor’s Guide.
49ERS (+4) over Rams
The 49ers secured one of the biggest upsets of the season in Week 5 when they defeated the Rams, 26-23, in overtime.
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San Francisco outplayed Los Angeles for the majority of the game, grabbing a 20-7 edge in the third quarter before the Rams rallied in the fourth quarter to force overtime.
This time around, the 49ers are at home and getting more than a field goal.
The Rams are the better team and rightfully favored, but the 49ers should keep this one close and can outright win this game.
Mac Jones has found his home in the Kyle Shanahan system — there’s a chance Brock Purdy returns for this game — and Christian McCaffrey can affect the game both as a rusher and a passer.
Jones completed 33 of 49 passes for 342 yards and two touchdowns in that contest, with Kendrick Bourne finding open lanes all night.
PANTHERS (-4.5) over Saints
Don’t look now, but the Panthers are suddenly NFC playoff contenders.
Sunday’s upset over the Packers gave them four wins in five games, and they now head home to welcome Tyler Shough for his second career start – and he won’t have Rashid Shaheed on his side.
Betting on the NFL?
If you take away the Bills debacle with Andy Dalton under center, the Panthers are 3-0 at home and averaged 29 points in those three victories over the Falcons, Dolphins, and Cowboys.
The Saints, meanwhile, are a disaster. They’ve lost each road game this year by at least 12 points, and just yielded 171 rushing yards to the Rams.
Whether Rico Dowdle is healthy or not, it won’t matter in this one. The Panthers are going to roll to an easy win and can win this game by a touchdown or more.
2025 record: 5-12-1
Last week: 1-1; 49ers (W); Lions (L)
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