Daniil Medvedev vs. Reilly Opelka odds, picks, and prediction

It’s been a trying year for former World No. 1 Daniil Medvedev.

The Russian has dealt with a number of injuries, which have caused his form to fluctuate throughout the season. Medvedev has only reached one final in 2025, and he’s lost to more than a handful of players outside the top 50, most recently to Benjamin Bonzi at Wimbledon.

Medvedev has had plenty of success during the North American hard-court swing in his career — he is a US Open champion, after all — so perhaps we see a strong close to the season from the Russian.

He is a big favorite over Reilly Opelka on Wednesday at the ATP Washington Open.

ATP Washington Open: Medvedev vs. Opelka odds, prediction

This is an intriguing battle between two very different players.

At the height of his powers, Medvedev was one of the best defensive players on the ATP Tour, and beating him essentially forced you to solve a puzzle. He is unorthodox, savvy, and could cover the court better than any player this side of Novak Djokovic.

The Russian’s game has tapered off this season, but he should have an advantage against Opelka, who is a one-dimensional player who relies on a massive serve to do damage.

Opelka’s defensive game still leaves plenty to be desired, but if his serve is working, he can be a chore. Medvedev found that out in a 6-7, 6-7 defeat to the American on the grass in June.

It’s a different ballgame in the heat on hard courts, conditions that should mute Opelka’s serve more than the grass did last month.

It’s been a while since Medvedev has been firing on all cylinders, but he should get off to a decent start in Washington against a player that shouldn’t provide too many surprises.

Back Meddy to get this one over the line quickly.

The Play: Medvedev -1.5 sets (-115, bet365 sportsbook)

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Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.