Shop Prime Day supplement deals for immunity, sleep, more up to 41% off

They say health is wealth, and that’s true, but it also can be expensive.

As someone who has shelled out serious cash for colostrums, protein powders and trendy supplements for my lady parts, I’ve come to count on my Prime membership to save and score serious deals on health and wellness products.

Prime Day (which started yesterday and finishes on July 11), has sort of become like another Christmas for me, as it’s one of the few times I’m almost guaranteed to find all my favorite vitamins and other self-care essentials at a much lower price.

I’m going to let you in on a little secret: You don’t have to wait until a new year to overhaul your health routine. You can start today. And to give you a little inspo (or fitsp, as we used to say in the toxic early aughts), I’ve rounded up some of the best Prime Day supplement deals to get you started.

NAD supplements are sort of trendy right now, but there’s actual science behind them. They support cellular energy production, fight inflammation and my personal fav health benefit — maintain cellular health (aka they’re anti-aging). My rec? The TRU NIAGEN PRO NAD+ Supplements. They’re clinical strength, have decades of research behind them, and boost NAD levels by over 50% in 2 weeks. They’re typically even pricier, so if you’re NAD-curious, Prime Day is the best time to grab them.

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My mother turned me on to The Super Orange-flavored Emergen-C 1000mg Vitamin C Powder for Daily Immune Support, and they are amazing. Any time I’m getting the sniffles, I put one of the packets in water and feel fine by the next day. They not only provide a healthy dose of the essential vitamin, but also have zinc, manganese, B vitamins for energy and electrolytes. I typically get a smaller box, but this one for Prime Day comes with 90 packs, which means you won’t have to repurchase until next year.

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I don’t eat fish every day, so I depend on an Omega supplement. Most people sleep on them, but they support brain and heart health. Solgar has been a trusted brand for years, and its 1300mg Omega 3-6 gives a concentrated blend of essential fatty acids from fish, flaxseed, and borage oils. Amazon shoppers give it a 4.7-star rating.

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When I saw this discount on the Garden of Life Multivitamin for Women, I almost pulled a muscle. Along with having 15 vitamins and minerals at 100% of the Daily Value (DV) or more, it also has a bunch of B vitamins and 2.5 mg of iron. Most multis can’t say that.

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Protein: Critical for muscle support and growth, healthy skin and cell repair — and lots of us aren’t getting enough. The Optimum Nutrition Gold Standard 100% Whey Protein Powder is a favorite of mine and more than 100K Amazon shoppers. A single scoop provides 24 grams of protein for only 120 calories, plus 29 servings come in this container, so you won’t have to restock anytime soon.

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You may be asking yourself, “Does collagen actually work?” I’m here to tell you that it absolutely does. I know because I take it almost every day.

Vital Proteins Collagen Peptides are a best-seller, and more than 20,000 Amazon customers have purchased it alone this month — that’s saying a lot, considering July just started. It has hyaluronic acid, plus vitamin C, the critical ingredient that makes it absorbable. Since I’ve added it to my routine, my nails and nails have become longer and stronger.

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Here me out, the O Positiv URO Vaginal Probiotics totally deserve a spot in your cart. Along with being third-party tested, vegan-friendly, gluten-free, and non-GMO, they have five different strains of gut-friendly bacteria that promote a healthy pH. I want to say more but will keep it PG. However, they’re an Amazon best-seller for a reason — just read the reviews on these and you’ll try them for yourself.

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Even if you’re not interested in ditching the coffee, RYZE Superfoods Mushroom Coffee is worth a try. It’s made with adaptogenic mushrooms, including lion’s mane and turkey tail, which improve endurance and boost immunity and energy levels. You can mix it with hot water, but I like it best as an add-on in one of my protein shakes. Seriously, give it a go, more than 80,000 Amazon shoppers have this month.

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Whenever my digestion is off, I take a shot of Dose. It’s made with milk thistle, dandelion and ginger — three things that promote better gut and liver health. It also has turmeric, a known anti-inflammatory. I’ve heard others call it everything from “magical” to “life-changing,” and it kind of is. Since taking it, I experience less bloating after meals. Three packs come in an order.

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For help falling (and staying) asleep, I rely on Moon Juice – Magnesi-Om. Magnesium regulates GABA neurotransmitters, which tell your brain to power down for the evening. The clinical strength blend also has L-Theanine, which I like to refer to as nature’s Xanax. It’s a compound from green tea and increases alpha brain waves, so you feel less anxious, making it easier to snooze. Trust, far better for you than a nightcap.

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Honestly, this list is barely scraping the surface of the number of Prime Day deals I found on supplements and other wellness must-haves, but this should get you started. But prices are ever changing, so I suggest grabbing them while you can.

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Your Prime Day FAQs, answered

How long does Prime Day last?

In a new twist for 2025, shoppers have 4 days to take advantage of Prime Day discounts. This sale starts on July 8 at 12:01 a.m. PT and runs through July 11 at 11:59 p.m. PT.

When does Prime Day end?

Prime Day 2025 ends on July 11 at 11:59 p.m. PT, so east-coasters have until about 3 a.m. on July 12 their time to shop the deals.

Do you have to have Amazon Prime to shop Prime Day?

Prime Day is a member-exclusive sale event. Interested shoppers can grab a 30-day free trial to try Prime, and its many benefits, with no strings attached.

What are the best Prime Day deals?

From reporting on Amazon sales throughout the years, we can tell you for certain that it’s the ideal period to stock up on household essentials, score great deals on vacuums, tech and appliances, refill your skincare empties, and comb through the massive catalog of Amazon best-sellers.

Is Prime Day worth it?

We certainly think so! Prime Day is a great chance to score Black Friday-worthy discounts on thousands of deals, including everything from big ticket items to Post reader-favorite trash bags. Our team diligently sorts through all the offers to find you the very best items to grab on sale.

When is the next Prime Day?

Already wondering when the next Amazon Prime Day is? Prime Day takes place in July each year, so it’s safe to assume it will take place in mid-July 2026 — similar to previous years. Can’t wait to shop more Amazon deals? Look out for Amazon’s Prime Big Deal Days sale, which typically runs in October for shoppers looking to beat the holiday rush of Black Friday.

Don’t miss Post Wanted’s around-the-clock coverage. Click here to find all of the best deals.

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For over 200 years, the New York Post has been America’s go-to source for bold news, engaging stories, in-depth reporting, and now, insightful shopping guidance. We’re not just thorough reporters – we sift through mountains of information, test and compare products, and consult experts on any topics we aren’t already schooled specialists in to deliver useful, realistic product recommendations based on our extensive and hands-on analysis. Here at The Post, we’re known for being brutally honest – we clearly label partnership content, and whether we receive anything from affiliate links, so you always know where we stand. We routinely update content to reflect current research and expert advice, provide context (and wit) and ensure our links work. Please note that deals can expire, and all prices are subject to change.

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